Manage Moods & Save Your Mind
Meaghen, a 42 year old senior financial analyst and married mother of four, had gotten so cranky that her husband and best friend from work scheduled an intervention.
“I was flabbergasted when Daniel and Brenda sat me down one evening and told me that my irritability and snappish comments were negatively impacting my team’s performance at work and my family’s willingness to come together for meals and events. I fired back at them, ‘You would edgy too if you had all I have on my plate.’ While they acknowledged my work load and stress levels, they continued to tell me: ‘Something has changed over the last year and a half. You are just not yourself.’ Finally Brenda mustered the courage to say, ‘I think your moodiness might be caused by your hormones – or lack of. Would you be willing to check out Dr. Randolph’s website, take his hormone imbalance quiz and possibly get your levels checked? I did and I feel like myself again for the first time in years. Please, Meaghen, give it a try. We really miss you.’”
“What could I say?” Meaghen shares, “I agreed to log onto the website. When I did, I felt as if I were looking into a mirror…one with a not too pleasant image of myself and my out-of-balance hormones. But, I found hope there too. I learned that it is possible to safely and naturally restore hormone balance to feel – and act – like yourself again. Within just three weeks on Dr. Randolph’s over-the-counter bioidentical hormone formulations, I was once again my calm, joyful, optimistic self. It was like coming home inside my own body and mind again.”
Moods and Irratability
Estrogen and progesterone play key roles in the regulation of moods, feelings of well-being and mental functioning. When progesterone levels first begin to fall and a young woman becomes estrogen dominant, her emotions and mental acuity suffer. For most women, the first signs of estrogen dominance are irritability, moodiness, depression, worsened PMS, low libido, abdominal weight gain, decreased energy and foggy thinking. Often younger women – and their physicians – do not think about “hormones”…the knee-jerk response is to simply write off the symptoms to stress or depression. OB/GYN’s are the #1 prescriber of anti-depressants in this country today.
As a woman moves into perimenopause, her ovaries’ production of estrogen starts to sputter meaning that sometimes her body will not produce enough estrogen to foster a menstrual cycle. Periods become irregular. Even though estrogen levels are ebbing and flowing irregularly, progesterone levels are slowing to almost nil so the condition of estrogen dominance continues to get much worse causing symptoms of moodiness/depression/irritability to also increase.
Another thing that happens during perimenopause is that a lot of women start having hot flashes and night sweats which interferes with a good night’s sleep. Lack of sleep is a double-negative whammy on moods Another thing that happens during perimenopause is that a lot of women start having hot flashes and night sweats which interferes with a good night’s sleep. Lack of sleep is a double-negative whammy on moods. And the ebb and flow of estrogen can increase a condition of depression because estrogen acts as a substantial multiplier of serotonin function by increasing the responsiveness of serotonin receptors.
Testosterone is the third hormone having an effect of emotions and moods. Testosterone is associated with feelings of wellbeing, energy and an overall positive outlook and enthusiasm for life. When testosterone levels begin to decline, or testosterone circulation is compromised by increased levels of sex hormone binding globulin (SHBG) associated with estrogen dominance, emotional well being usually suffers.
Mental Functioning
Andrew, a 48 year old medical equipment salesman and divorced father of two teenagers, recently emailed us:
“Dr. Randolph and Genie, for the last couple of years I have been desperately worried that I might be suffering from early Alzheimer’s disease. My memory had always been a source of pride but increasingly I couldn’t remember names, scheduled appointments or special events like my sons’ birthdays. And sales is all about details and follow up so it was inevitable that my work began to suffer. Then one of the doctors I call on told me about you and your website and suggested that my hormones – or lack of - might be the source of my ever-increasing brain fog. I was skeptical but, only one month after taking your Hormone Imbalance Quiz and starting on your recommended over-the-counter bioidentical formulations, I am a sharp-minded true believer. I can’t thank you all enough.”
Alzheimer’s Disease International reported that more than 5 million people in the United States and 35 million people around the world are living with Alzheimer’s disease or other types of dementia. The disease is epidemic, killing more people than breast and prostate cancer combined.
While age is the variable most commonly associated with Alzheimer’s and the medical community also recognizes a link between cognitive decline and obesity, high cholesterol and diabetes, most physicians and lay people are unaware of how age-related hormone level decline is a pivotal variable impacting memory, learning and overall cognitive function.
Dr. Randolph tells us, “It is a widespread belief that Alzheimer’s or ‘old, tired brain syndrome’ is a sad but unavoidable consequence of aging – when it’s not. There are millions of hormone receptor sites throughout the body, including the brain. When production of needed hormones sloughs off due to the aging of the ovary or testes, your brain’s hormone receptors go lacking and the result is impaired mental activity. Maintaining optimum hormone balance no matter your age is a critical first step to supporting optimum cognitive function for life.”
“Most women actually begin to experience ‘foggy brain syndrome’ in their mid to late-30’s,” continues Dr. Randolph. “These are the years when the ovaries production of estrogen and testosterone remains relatively stable while progesterone production begins to rapidly decline creating a hormonal imbalance at a cellular level that is medically-termed ‘estrogen dominance’. Bioidentical progesterone supplementation is one of the most proactive steps anyone can take to keep their mind sharp and agile.”
As a woman moves toward menopause, the mood disruptions/depressions/anxiety associated with the decline of all three sex hormones – estrogen, progesterone and testosterone – have been clinically shown to make it more difficult for women to encode, or learn and keep, new information stored in their brain. Men have a similar experience though hormone production decline, particularly testosterone levels, usually starts to impact a man in his 40’s. In addition to memory and clarity of thought, energy levels are also negatively impacted by this downward shift in hormone production.
“Bottom line is that at a cellular level, the body may not be able to produce the all the chemical messengers it used to produce – and still needs – for optimal cognitive functioning,” concludes Dr. Randolph, “but no one should simply throw in the towel and become resigned to getting senile. The first step is to replace the progesterone your body – and brain - are so sorely missing. Also consider having your hormone levels tested with one of our Hormone Well Test Kits to find out if you may also be deficient in estrogen and/or testosterone.”
“Medical studies have also shown Vitamin E to have promise for slowing down Alzheimer’s disease,” shares Genie James. “In addition to Vitamin E supplementation, dietary sources of Vitamin E include wheat germ oil, almonds, sunflower seeds/oil, spinach, broccoli, kiwi, mangoes, peanuts…Foods rich in beta carotene have also been found to have positive effects on cognitive function. In addition to carrots, dark green veggies are also good dietary sources of beta carotene. B12 plays a key role in the synthesis of neurotransmitters, those messengers communicating between nerves of your brain. In addition to B12 supplementation, good dietary sources of B12 include salmon, red meat and dairy products. Finally, a new study now suggests that low levels of vitamin D may even reduce brain function in older people. This study published in the Journal of Geriatric Psychology and Neurology looked at 1,766 older people. After assessing their level of cognitive function, they measured blood levels of vitamin D. It was found that the older people with lower cognitive function had low levels of vitamin D in their bloodstream, while those with normal brain function had higher levels. In fact, those subjects with the lowest levels of vitamin D were four times more likely to suffer from brain impairment compared to those with the highest levels.”
Start with the science! Click here for references.
Local synthesis and dual actions of Progesterone in the nervous system: neuroprotection and myelination. Schumacher M, Guennoun R, Robert F, Carelli C, Gago N, Ghoumari A, Gonzalez Deniselle MC, Gonzalez SL, Ibanez C, Labombarda F, Coirini H, Baulieu EE, De Nicola AF. Growth Horm IGF Res. 2004;14 Suppl A:S18-33.
Blokland A, Honig W, Brouns F, Jolles J (October 1999). "Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS". Nutrition 15 (10): 778–83. PMID 10501292.
Crook, T. H.; R. M. Klatz (ed) (1998). Treatment of Age-Related Cognitive Decline: Effects of Phosphatidylserine in Anti-Aging Medical Therapeutics. 2. Chicago: Health Quest Publications. pp. 20–29.
Kidd PM. Dietary phospholipids as anti-aging nutraceuticals. In: Klatz RA, Goldman R, eds. Anti-Aging Medical Therapeutics. Chicago, IL: Health Quest Publications; 2000:283-301.
Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr 1994;14:269-296.
Take Action Today
- Take our Hormone Imbalance Quiz.
- Start with Dr. Randolph’s over-the-counter bioidentical progesterone cream, Natural Balance Cream.
- Order one of our Hormone Well Test Kits to find out exactly what is going on with all the hormones inside your body, particularly estrogen, testosterone, DHEA and the stress hormone cortisol.